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These were also mild in severity and transient, and resolved spontaneously. No consistent changes suggestive of a treatment effect in heart rate were observed, and no subject had a clinically significant change in ECG findings. The results of what are sildenafil teva tablets used for the present studies define the pharmacokinetic attributes that support the therapeutic efficacy of sildenafil, particularly when taken as needed. In the present studies, what are sildenafil teva tablets used for sildenafil exhibited rapid oral absorption, as judged by the achievement of peak plasma concentrations at approximately 1 h postdose. This observation is consistent with the findings of Walker et al.
A modest, albeit statistically significant, reduction in the rate of absorption and no change in extent of absorption were observed when sildenafil was taken with food (high-fat meal), as compared to dosing in the fasting state. As a consequence of the effects of food on sildenafil pharmacokinetics, a similar picture was seen for its primary circulating metabolite, UK-103,what are sildenafil teva tablets used for 320. The latter study also observed a statistically significant delay in sildenafil absorption (by 0.7 what are sildenafil teva tablets used for h, P −1) approximates the rate of hepatic blood flow in man, indicating that the liver is the predominant route of elimination of sildenafil as described what are sildenafil teva tablets used for by Hyland et al.