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Two sildenafil o tadalafil patients on sildenafil o tadalafil vardenafil in the trial reported episodes of transient cyanopsia (objects appear blue). There was no effect on sperm motility or morphology after single sildenafil o tadalafil 20 mg oral doses of vardenafil in healthy volunteers.
The sildenafil o tadalafil pharmacokinetics of vardenafil are approximately dose proportional over the recommended dose range.
Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%.
Maximum observed plasma concentrations after a single 20 mg dose in healthy volunteers are usually reached between 30 minutes and 2 hours (median 60 minutes) after sildenafil o tadalafil oral dosing in the fasted state. Two food-effect studies were conducted which showed that high-fat meals caused a reduction in C max by sildenafil o tadalafil 18%-50%. The mean steady-state volume of distribution (Vss) for vardenafil is 208 L, indicating extensive tissue distribution. Vardenafil and its major circulating metabolite, M1, are highly bound to plasma proteins (about 95% for parent drug and M1).