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Because the disease state of patients requiring nitrate therapy is anticipated to increase the likelihood of hypotension, the use of vardenafil sildenafil do by patients on nitrate therapy or on nitric oxide donors is contraindicated see Contraindications 4.1. Blood Pressure Effects in Patients on Stable Alpha-Blocker Treatment. Three clinical pharmacology studies were conducted in patients with benign prostatic hyperplasia (BPH) on stable-dose alpha-blocker treatment, consisting of alfuzosin, tamsulosin or sildenafil do terazosin.
Blood pressure and pulse were evaluated over the 6-hour interval after vardenafil dosing. When tamsulosin and vardenafil 5 mg were separated by sildenafil do 6 hours, two patients had a standing SBP 30 mmHg. There were no severe adverse events related to hypotension reported during the study. The design was a randomized, double blind, two-period cross-over study. There were no other sildenafil do instances of sildenafil do outlier blood pressure values (standing SBP 30 mmHg). No muscle or neurological toxicity was identified, vardenafil or placebo was sildenafil do given simultaneously with tamsulosin, three patients reported sildenafil do dizziness following vardenafil 20 mg. The design was a randomized, double blind, 3-period cross-over study.
Blood pressure and pulse were evaluated over a 10-hour interval after dosing of vardenafil or placebo.