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A starting oral dose of 25 mg should viagra tablet description viagra tablet description be considered in those patients (see DOSAGE AND ADMINISTRATION) Sildenafil metabolism is principally mediated by CYP3 A4 (major route) and CYP2 C9 (minor route). Therefore, inhibitors of these isoenzymes may reduce sildenafil viagra tablet description clearance and inducers of these isoenzymes may increase sildenafil viagra tablet description clearance. The concomitant use of erythromycin or strong viagra tablet description CYP3 A4 inhibitors e.
Saquinavir, ketoconazole, itraconazole as well as the nonspecific CYP inhibitor, cimetidine, is associated with increased plasma levels of viagra tablet description sildenafil (see DOSAGE AND viagra tablet description ADMINISTRATION) Viagra had no effect on saquinavir pharmacokinetics. A stronger CYP3 A4 inhibitor such as ketoconazole or itraconazole could be expected to have greater effect than that seen with saquinavir.
At 24 hours the plasma levels of sildenafil were still approximately 200 ng/mL, compared to approximately 5 ng/mL when sildenafil was dosed alone. This is consistent with ritonavir's marked effects on a broad range of P450 substrates. VIAGRA had no what is viagra spray effect on ritonavir pharmacokinetics (see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS) Although the interaction between other protease inhibitors and sildenafil has not been viagra tablet description studied, their concomitant use is expected to increase sildenafil levels.