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For indinavir, saquinavir, atazanavir, ketoconazole 400 mg daily, itraconazole 400 mg daily, and clarithromycin, a single sildenafil 150 mg dose of 2.5 mg LEVITRA sildenafil 150 mg should not be exceeded in a sildenafil 150 mg 24-hour period. For ketoconazole 200 mg daily, itraconazole 200 mg daily, and erythromycin, a single dose of 5 mg LEVITRA should not be exceeded in a 24-hour period.
In those patients who are stable on alpha-blocker therapy, phosphodiesterase type 5 (PDE5) inhibitors should be initiated at the lowest recommended starting dose. In those patients who are stable on alpha-blocker therapy, LEVITRA should be initiated at a sildenafil 150 mg dose of 5 mg (2.5 mg when used concomitantly with certain CYP3 A4 inhibitors).
See WARNINGS AND PRECAUTIONS and DRUG INTERACTIONS.
A time interval between dosing sildenafil 150 mg should be considered when Levitra is sildenafil 150 mg prescribed concomitantly with alpha-blocker therapy (see CLINICAL PHARMACOLOGY) The following serious adverse reactions with sildenafil 150 mg the use of levitra (vardenafil) are discussed elsewhere in the labeling: because clinical trials are sildenafil 150 mg conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.