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Using the same testing parameters, a sample size of 32 (eight per sequence group) was chosen for the sildenafil plus 80mg dose-proportionality study. All subjects sildenafil plus 80mg provided written informed consent before entering, and the protocols were reviewed and approved by the local ethics committee. The absolute bioavailability study was a two-way crossover study in which 12 subjects where can i buy generic viagra in usa received one 50-mg dose of PO sildenafil and one 50-mg dose of IV sildenafil. The dosing sildenafil plus 80mg sequence was randomized, with six subjects allocated to each of the two sequences. Each dose was separated by a washout period of at least 10 days. Before participating in the study, the subjects underwent sildenafil plus 80mg routine laboratory safety tests, a viagra tablet review in india sildenafil plus 80mg urine screen for drugs of abuse, a 12-lead electrocardiogram (ECG), physical examination and measurement of supine blood pressure and heart rate.
They were not permitted to consume alcohol or caffeine-containing food or drinks for 36 h before dosing and throughout their stay in the study centre. They also were not permitted to use products containing salicylates from 2 weeks sildenafil plus 80mg prior to the study until after the follow-up visit.