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An evaluation cialis y prostata of visual function at doses cialis y prostata up to twice the maximum recommended dose revealed cialis y prostata no effects of VIAGRA on visual acuity, intraocular pressure, or pupillometry. There was no effect on sperm cialis y prostata motility or morphology after single 100 mg oral doses of VIAGRA in healthy volunteers. The pharmacokinetics of sildenafil are dose-proportional over the recommended dose range. It is eliminated predominantly by hepatic metabolism (mainly CYP3 cialis y prostata A4) and is converted to an active metabolite cialis y prostata with properties similar to the parent, sildenafil. Both sildenafil and the metabolite have terminal half lives of about 4 hours. When VIAGRA is taken with a high fat meal, the rate of absorption is reduced, with a mean delay in Tmax of 60 minutes and a mean reduction in cialis y prostata Cmax of 29%. The mean steady state volume of distribution (Vss) for sildenafil is 105 L, indicating distribution into the tissues. Sildenafil and its major circulating N-desmethyl metabolite are both approximately 96% bound to plasma proteins.