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In viagra side effects blood in urine addition, in the absolute bioavailability study, clearance (CL) and steady state volume of distribution (V ss) were calculated after IV dosing, together with an estimate viagra side effects blood in urine of absolute bioavailability (F). In all studies, laboratory safety viagra side effects blood in urine tests and physical examinations were performed prior to dosing and at regular intervals postdose. Supine blood pressure, heart rate and 12-lead ECG were also monitored throughout the absolute bioavailability study. The nature viagra side effects blood in urine and severity of all observed or volunteered adverse events and the investigator's assessment of the relationship of each adverse event to study treatment were recorded throughout the studies. For the absolute bioavailability study, natural log-transformed AUC and viagra side effects blood in urine C max and untransformed t max and k el data were subjected to analyses of variance (anova) appropriate to the study design. For C max and AUC data, the means and 90% viagra side effects blood in urine CI were computed on the logarithmic scale and then back transformed to give the ratio and CI on a nominal scale.