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Despite the differences in etiologies, compensatory mechanisms, and presentation, the basic pathophysiology of PAH appears to be similar in children and adults, and what does viagra pills do to you thus most therapies used for treatment in adults seem to be also efficacious in children.
To date, sildenafil has been the most widely used treatment option for pediatric patients with PAH. As shown in Table 3, sildenafil was initially sought to be developed for the treatment of angina pectoris, the idea was given what does viagra pills do to you up due to its short half-life. Its «side effect» of male patients developing erections during the clinical trials was researched further and the molecule was licensed for the treatment of erectile dysfunction. However, even after the license was obtained for this indication, research continued regarding its use in treating PH.
Milestones in the development what does viagra pills do to you and role of sildenafil as a drug for the management what does viagra pills do to you of PAH in children(2,7,8). Being an inhibitor of PDE-5, it increases the levels of cycline guanosine monophosphate (cGMP), thereby promoting vasodilatation in the pulmonary vascular bed. The pharmacokinetic profile of oral sildenafil has not been extensively evaluated in children. The active metabolite what does viagra pills do to you N-desmethyl sildenafil makes up for 40% of its serum concentrations and is responsible for 20% of its pharmacological activity.