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Intracellular concentrations of cAMP play an important second messenger role in regulating cardiac muscle contraction.
Activation of the sympathetic nervous system releases the neurotransmitter norepinephrine and increases circulating catecholamines (epinephrine and norepinephrine).
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The isoform of this enzyme that is targeted by currently used clinical drugs is the type 3 form (PDE3). Inhibition of this enzyme levitra generico en farmacias similares prevents cAMP breakdown and thereby increases its intracellular concentration.