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For k el and t max, means and 90% CI were calculated without transformations and compared between treatments. For the dose-proportionality study, an anova appropriate to the study viagra occasional use design was performed on natural log-transformed dose-normalized AUC, C max, t max and k el values for viagra occasional use sildenafil.
Ninety percent CIs for the differences between viagra occasional use treatment means (25 mg vs 50, 100 and 200 mg, 50 mg vs 100 mg, and 100 mg vs viagra occasional use 200 mg) and standard errors associated with these differences were calculated.
For normalized AUC and C max, the mean difference and 90% CI were back transformed to obtain the viagra occasional use mean ratio of treatments and 90% CI for the ratio. Using a linear model, data were considered to be dose proportional if the normalized AUC and C max CI for the ratios were within the interval of 80–125%, and if there were no significant differences between treatments for mean t max and k el.