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Plasma concentration profiles for sildenafil and UK-103,320 are shown in Figure 2. Geometric means levitra 20 kullan?m? are presented for AUC, AUC t and C max, arithmetic means are presented for t max and k el and harmonic means are presented for t 1/2.
Fasted ratios for AUC and C max were derived from comparing the geometric means for these parameters. Plasma concentrations of UK-103,320 (C max and levitra 20 kullan?m? AUC) were approximately 45% of those of the parent drug. Although no formal statistical analysis was conducted on the metabolite parameters, the relationship between sildenafil dose and UK-103,320 pharmacokinetics was similar to that for sildenafil itself.
Sildenafil was well tolerated in all three studies. The most was kostet sildenafil 100mg in der apotheke commonly reported treatment-related adverse events were nausea, headache, abnormal vision, dizziness, limb pain, eye pain and vasodilatation, all were mild to moderate levitra 20 kullan?m? in severity and transient. There levitra 20 kullan?m? were no reports of serious adverse events or treatment-related laboratory levitra 20 kullan?m? abnormalities. In the dose-proportionality trial, levitra 20 kullan?m? the incidence levitra 20 kullan?m? of adverse events increased with sildenafil dose.